Haemophillia type A genetic disease Essay Example | Topics and Well Written Essays - 1500 words

Haemophillia type A genetic disease - Essay Example At times, there occurs a change in genes or mutation which alters the instructions present in genes for protein making. Then the protein either misses entirely or stops working properly, causing certain medical condition known as genetic disorder. So, a genetic disease refers to a disorder or illness that is caused by one or multiple defects and abnormalities present in the genome. It is particularly caused by a certain condition which is congenital (present since birth). Such disorders are usually rare to occur and, in several thousand, only one person is affected (Griffiths, Anthony; Wessler, Susan, Carroll, Sean, Doebley, John, p. 57). The genetic abnormality in many people may range from minor to major, or in other words, from a single base discrete mutation in the DNA of a single gene to a gross chromosome abnormality connecting the subtraction or addition of a set of chromosomes or chromosomes on whole. There are different types of genetic disorders; some are passed down to children from parents, while many other genetic abnormalities occur due to mutations or acquired changes in a preexisting group of genes or gene. It is usually due to the various environmental exposures that gene mutations occurs (MedicineNet). The disorders caused by mutation of genes may not be heritable sometimes, i.e., passed down to offspring from parents genes. The genetic disorders that are non-heritable as they may be defected by the new changes or mutations to the DNA. In these situations, if the defect occurs in germ line, only then, it will be heritable. On the other hand, the inherited genetic conditions in some people may be the reason for the occurrence of same disease, such as a particular type of cancer (Kuliev, Verlinsky, p.179–83). This happens mainly through the environmental reasons and also by new mutations in many other people. The inherited deficiencies of coagulation factors include Hemophilia A and B, also known as

BLOBs in database Essay Example | Topics and Well Written Essays - 1000 words

BLOBs in database - Essay Example The storage and retrieval of these items can be accomplished through a database system using a column type capable of storing binary data (commonly referred to as a "binary large object" or a BLOB). There are many existing database systems capable of storing BLOBs. Such systems' functionality, performance and cost vary greatly among vendors (with some costing as much as $25,000 for a single CPU license). The prohibitive cost often keeps some organizations from conducting full assessments of database systems for possible use in their operations, potentially causing a loss or revenue. Entities with limited resources need an affordable means of assessing or benchmarking their own database utilization. This thesis, first and foremost, provides a database benchmark for storing BLOBs in a database. Secondly, a database benchmark framework is provided with the example implementation being the BLOB database benchmark. By so doing: My research indicates that no research has been done comparing the performance of database systems' ability to store BLOBs. ... The software development community will now have a benchmark for storing BLOBs in a database. This benchmark will fill a void as most database benchmarks focus on OLTP (online transaction processing) that consist of very small records and none focus on the general storage of BLOBs. EXISTING DATABASE BENCHMARKS My research indicates that no research has been done comparing the performance of database systems' ability to store BLOBs. Similar research regarding database performance (for datasets not including binary data) does exist and come from the following sources: the Transaction Processing Counsel (TPC), Storage Performance Council (SPC), Open Source Database Benchmark (OSDB), Engineering Database Benchmark (EDB) and Wisconsin Database (Bitton). In addition to not considering BLOBs, the TPC and SPC benchmarks are implemented by vendors who perform many specialized database and operating system configurations. Thus, they are not pertinent to this discussion. These nonstandard configurations take advantage of the vendors' specialized knowledge of the hardware, database, operating system and benchmark. This thesis provides the first benchmark to assess the storage of BLOBs in relational database systems. The performance results are categorized into three general BLOB sizes: small, medium a nd large. Below is a brief description of the five similar database performance resources. Transaction Processing Council (TPC) Each TPC benchmark consists of a set of functional requirements to be run on any transaction processing system independent of the hardware or operating system. It is then up to the test sponsor to submit proof (in the form of a full disclosure report) that they have met all the requirements. The TPC has four non-obsolete database benchmarks: